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When Madeson shared his data with Knudsen in 1995, she realised that it rang a bell because she had noticed that both normal and obese rates experienced a lasting and reversible weight loss when given one of her early GLP-1 analogues
Originally developed to regulate blood sugar in people with diabetes, GLP-1 treatments have been clinically proven to also support significant, sustained weight loss
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Cardiovascular disease remains the leading cause of death among people with obesity, with overlapping drivers including insulin resistance, dyslipidemia, inflammation, sleep apnea, and hemodynamic load
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