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Rational combination strategies that concurrently target hypoxia signaling, metabolic vulnerabilities, angiogenesis, and immune checkpoints may ultimately overcome compensatory adaptations
In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]
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