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In 2023, Lopez-Otin proposed twelve markers of aging, including genomic instability, telomere loss, epigenetic changes, loss of protein balance, failure of macroautophagy, dysregulated nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell depletion, altered intercellular communication, chronic inflammation, and dysbiosis

Graphical abstract Similar content being viewed by others Background Nephropathic cystinosis is a rare, autosomal recessive lysosomal storage disease with an incidence of 1:100,000 to 1:200,000 live births [1]

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However, the apo system exhibited larger standard deviations (S2A Fig)