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Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
The functional prediction performed using phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) and Kyoto encyclopedia of genes and genomes (KEGG) implicated that the depleted gut microbiome was associated with metabolic pathways, including those related to carbohydrates, butanoate, and amino acids (Supplementary Fig
Reduced levels of tumor necrosis factor-alpha (TNF-) and MMPs indicated lower inflammation and enhanced tissue remodeling (Canapp et al., 2003)
