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doi: 10.3389/fendo.2022.934775 Received 03 May 2022 Accepted 28 June 2022 Published 26 July 2022 Volume 13 - 2022 Edited by Quan Zhang, University of Oxford, United Kingdom Reviewed by Beatriz Merino, University of Valladolid, Spain

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83 Autotaxin inhibits autophagy via the AMPK pathway, thereby disrupting the mucosal barrier and aggravating intestinal inflammation, and AMPK agonists can significantly ameliorate this process, preventing intestinal inflammation and maintaining the integrity of the mucosal barrier