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From what I have observed in the research community, the people who have the smoothest experience are those who respect the titration process

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If GLP-1 receptor agonism, and by extension the dual and triple agonists, and possibly the cleaner endogenous peptides like BRP, operates as a class of geroscience interventions rather than a class of weight-loss drugs that happen to have nice cardiovascular side benefits, then the population for whom these molecules might matter is much larger than the population that currently qualifies for them under any obesity- or diabetes-based prescribing guideline