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Keywords: melanin index, melanogenesis, oxidized glutathione, reduced glutathione, skin whitening, topical Introduction Skin aging is a complex biological phenomenon consisting of two independent clinically and biologically distinct processes, namely intrinsic aging and extrinsic aging. 1,2 Extrinsic aging (including photoaging) is the result of exposure to outdoor elements, primarily ultraviolet (UV) irradiation

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The preference of mammalian and bacterial glutaredoxins for GSSR highly depends on the -glutamyl moiety of glutathione 40,41,42

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Considerations Before Starting Therapy Consult a Healthcare Professional : Always seek advice from a clinician before beginning glutathione infusiontherapy

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