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REDEFINE 1 (Garvey et al., NEJM 2025) is the only Phase 3 trial of an amylin + incretin co-administered combination, pairing cagrilintide 2.4 mg with semaglutide 2.4 mg
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Peptide therapies like AOD9604 or tesamorelin can play a complementary role in bodycomposition and metabolic wellness, but outside of tesamorelins HIV indication, their weightloss evidence base is smaller and they should be framed as adjunctive tools rather than replacements for wellstudied GLP1 treatments
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