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Although these and other data support the possible use of inositol hexaphosphate-loaded erythrocytes as effective treatments to improve the delivery of O 2 to tissues in need, there is an ongoing debate about the advantages of higher or lower hemoglobinoxygen affinity in humans, particularly during hypoxia (Webb et al., 2021) that require further investigations

To help prevent dehydration, Lowe Clayton recommends drinking plenty of water, avoiding sugary drinks, and adding electrolytes when appropriate

For once-weekly preparations such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity), the time of day is generally less critical because these long-acting formulations maintain steady drug levels throughout the week

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