Contraindications: Who Shouldnt Use Semaglutide Semaglutide is contraindicated in specific populations: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Previous serious hypersensitivity to semaglutide Pregnancy (should be discontinued at least two months before planned pregnancy) History of pancreatitis Severe gastrointestinal disease Diabetic retinopathy Kidney disease Depression or suicidal behavior: Providers monitor for new or worsening depression or suicidal thoughts and treatment should be discontinued if these symptoms develop Please note that it's highly important to discuss your health history with your healthcare provider before taking a GLP-1, especially if any of the above apply to you
NASH/MASH Studies: Phase 2 trials have evaluated the compound in non-alcoholic fatty liver disease, with reductions in liver fat observed
Switching from Semaglutide to Tirzepatide When Plateaued When Zepbound no longer delivers weight loss progress, clinical data supports switching to tirzepatide rather than continuing semaglutide escalation
2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events A 2024 Meta-analysis of 13 multiple cardiovascular outcome trials has documented that GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)