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For patients with type 2 diabetes, coordination between endocrinologists, primary care physicians, and specialists is essential to prevent hypoglycemia when tirzepatide is combined with insulin or sulfonylureas

Studies show GLP-1s help decrease weight, improve metabolic complications, lower flares and stiffness, and may slow joint damage when combined with DMARDs or biologics

But none had been isolated with incretin-like properties first described by La Barre which was considered to be ideal for the treatment of type 2 diabetes (Marks Samols

SELECT showed that group gets significant MACE reduction, which is a mortality-relevant outcome