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Generally, the best candidates are women under the age of 60 or within 10 years of menopause onset who have bothersome symptoms, and don't have contraindications to systemic hormone therapy (which include a history of blood clots and certain types of cancer, like breast cancer), according to Faubion

Decreasing the risk of birth defects in pregnant women

Coverage usually requires prior authorization, including documentation of a Type 2 diabetes diagnosis, recent A1C results, and evidence that other diabetes medications (such as metformin or sulfonylureas) have not adequately controlled blood sugar

One reason your body builds more lean muscle tissue when you take creatine is that your muscles will hold more water