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A World Expert Eyes Gene Therapy Patients come to Michael Schilsky, MD, a Yale Medicine gastroenterologist and hepatologist, after struggling for yearssometimes decadeswith a range of symptoms such as extreme fatigue, jaundice, personality changes, stutters, and movement issues (such as clumsy hands)
As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury
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Kumar SD, Kar D, Akhtar MN, Willard B, Roy D, Hussain T, et al
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