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The state insurer implemented coverage restrictions that aligned with the broader BCBS trend, removing weight management as a standalone covered indication
It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
Semax and Selank offer valuable complementary effects particularly for anxiety modulation and acute cognitive clarity with a simpler nasal spray format
The protocol for this trial and supporting CONSORT checklist are available as supporting information
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