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doi:10.1053/j.gastro.2019.09.041 85Park SC, Jeen YT

Senescent cells secrete the senescence-associated secretory phenotype (SASP), which consists of inflammatory cytokines and chemokine growth factors, into the surrounding tissues

While oral absorption is limited for B12, taking very high doses (e.g., 1000mcg or 2000mcg) can allow for a small amount of passive absorption that doesnt rely on intrinsic factor

doi: 10.1016/j.conctc.2021.100780