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Some studies suggest that prolonged or excessive mTOR inhibition may impair muscle protein synthesis and potentially exacerbate sarcopenia in older adults, highlighting a possible trade-off between metabolic benefits and preservation of lean massan area requiring further investigation [28]

In addition to normal physical examination findings, electrocardiogram indicators and liver and kidney function-related biochemical markers, as well as blood and urine test results, were within normal ranges, confirming the absence of toxicity across all tested UA doses

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