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A significant overdose (double dose or more) warrants immediate medical attention
hypoglycemia risk if on insulin) eGFR below 30 (tirzepatide exclusion in SURMOUNT-5) Recent cardiac event or NYHA Class IV heart failure Active suicidal ideation (trials excluded PHQ-9 scores of 15 or above) If your tirzepatide vs semaglutide question is pure weight loss without comorbidities, tirzepatide wins on the numbers
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