glp 1 mechanism Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 Structure-Based Discovery of Orthosteric Non-Peptide

You get less flight time this way but it might be worth the trade off to you

In immortalised human airway epithelial cell lines (including bronchial epithelial cells) and human alveolar epitheliallike cells, GLP-1 receptor agonists reduced epithelial stress and inflammatory signalling, including downregulation of epithelial-derived cytokines, including IL-33 and thymic stromal lymphopoietin (TSLP), both of which are implicated in epithelialmesenchymal crosstalk and fibroblast recruitment in fibrotic lung disease [66,67,68]

Payahoo L, Khajebishak Y, Alivand MR, Soleimanzade H, Alipour S, Barzegari A, et al

Menopause Transition & Body Composition There are very few meaningful differences between men and women in nutrition During the menstrual cycle, cravings go through the roof for about a week Strategy: Use diet breaks go hard for 3 weeks, then ease up during the period week Dont fight Mother Nature, ride with it instead Coincide your higher calorie week with your menstrual cycle For menopause: a lot of scaremongering, but actual changes arent that dramatic SWAN study (biggest/longest study) showed an average of 3.5 lbs fat gain and 0.5 lbs muscle loss over 3-4 years This is the general population, not fitness people with high protein/resistance training Set expectations at maybe 50% the rate of progress during menopause transition Instead of 1 lb/week weight loss, maybe expect 0.5 lb/week The symptoms (hot flashes, poor sleep, joint pain) make adherence harder, not the physiology itself 02:07:04 Collagen Supplementation, Skin Appearance Evidence-based fitness people are weirdly pathological about avoiding supplements Collagen is the single most abundant protein in the body (20-40% of total body protein) Makes up significant amounts of bone, joints, ligaments, tendons, and skin Skin is 80% collagen by dry weight Why do people accept taking calcium for bones but get weird about collagen for connective tissues