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The system xc - , which plays a role in importing cysteine for GSH synthesis, is a significant upstream modulator in this process
In human trials, decreased appetite was one of the most commonly reported effects
GLP-1+GIP dual-agonists - such as tirzepatide - add a second mechanism: mimicking GIP (glucose-dependent insulinotropic polypeptide), which targets additional hormonal pathways involved in appetite and blood sugar regulation
That hasnt stopped pharma companies from pursuing GIP as a target
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