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Mutations in the PCSK1 gene are responsible for rare but severe forms of monogenic early-onset obesity ( PCSK1 gene result in impaired cleavage of these hormone precursors, leading to hyperphagia, severe obesity, and multiple discordance of the endocrinopathies, such as adrenal insufficiency, hypogonadism, and malabsorptive diarrhea in infancy
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Nausea is most common during dose escalation
Athanassakis I, Dionyssopoulou E, Papanikou S, Evangeliou A, Vassiliadis S
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