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Mounjaro (tirzepatide) tends to produce greater weight loss in clinical studies and targets two receptors versus one
The exception: in March 2024, the FDA approved a supplemental indication for semaglutide 2.4 mg (Wegovy) to reduce the risk of cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke in adults with established cardiovascular disease and either obesity or overweight (SELECT trial, Lincoff et al., New England Journal of Medicine 2023)
Not to exceed the recommended daily usage
What Happens When You Stop Taking GLP-1 Medications Weight regain is common after stopping GLP-1 therapy if lifestyle changes alone are not maintained
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