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doi:10.1093/emph/eoab031 Lvovskaya S, Smith DP

Side Effects and Tolerability Comparison Both tirzepatide and semaglutide share common side effects including nausea, vomiting, constipation, and diarrhea, particularly during the first few weeks of treatment

What Normal Reactions Look Like Across large studies of injectable biologics, typical benign reactions include: Mild redness confined to 2-3 cm around the injection site Slight swelling or firmness (small lump or wheal under skin) Tenderness or itching improving within hours to two days Minor bruising or pinpoint bleeding Timeline: Onset within minutes to 24 hours, peaking by 24 hours, followed by improvement Clinical data shows these reactions occur in 25-45% of injections for some formulations and usually resolve within 1-3 days with simple care