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In the PIONEER programme [35,36,37,38,39,40,41,42], the most frequent adverse events were nausea and diarrhoea, which are common side effects of GLP-1 analogues
The goal is to avoid significant appetite suppression, which could lead to underfueling and negatively affect performance and recovery
G., Kleiner, S
Nausea, vomiting, diarrhea, and constipation affected 60 to 80% of participants at higher doses, though most symptoms were mild to moderate in severity
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