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There are tremendous challenges when transitioning other novel agents from bench-to-bedside, such as the issue of showing efficacy for regulatory approval when resistance develops so fast
Additionally, urinary excretion of glutathione and cysteine surged significantly by 300-fold and ten-fold, respectively within just 90 minutes [7]
New trial designs, such as adaptive, biomarker-driven, and crossover studies are increasingly used to overcome problems of inter-individual variability in response, bioavailability and metabolism (233)
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