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As with any supplement, periodic breaks (three months on, one month off) are a reasonable precautionary approach, particularly for individuals with no confirmed deficiency or elevated oxidative stress markers

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Estrogen binding to estrogen receptor- (ER-) in osteoblasts induces the expression of Fas ligand (FasL), which activates the Fas/FasL extrinsic apoptotic pathway in osteoclasts, thereby limiting osteoclast lifespan

Only the R -enantiomer is endogenously synthesized and covalently bound to protein