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Sjostrom L, Peltonen M, Jacobson P, Ahlin S, Andersson-Assarsson J, Anveden A et al
: (Tirzepatide) (Semaglutide) 2 ( TRANSCENDT2D2 T2D3)
Our observation that L-cells not only release GLP-1 and PYY but also secrete ATP, which, as re-established here, is a potent activator of ND neurons, has implications for how we perceive the interplay between enteroendocrine cells, as primary sensors located in the epithelium layer and their secondary neuronal targets
Each single-compound approach has a different dosing logic than the combination, and the comparison clarifies why the combination dosing is designed the way it is
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