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Thus, obesity and IR seem to compose the first steps in the development of non-alcoholic fatty liver disease, without, however, all the pathogenesis and evolution of NAFLD to steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma, with the possible absence of cirrhosis in children, being completely established ( 28 )
However, the argument was refuted for the strain Z8 when grown in a chemically defined medium (CDM) and it was found only to accumulate GSH from the medium [19]
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