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Potential considerations include: Theoretical concern about promoting angiogenesis in existing tumors (not demonstrated but mechanistically plausible) Possible interactions with dopaminergic medications Limited human safety data due to absence of completed clinical trials GHK-Cu Side Effects# GHK-Cu has an established safety profile, particularly for topical use: Topical formulations are generally well-tolerated with low irritation potential Allergic reactions are rare but possible, particularly in individuals with copper sensitivity Injection site reactions (redness, swelling) can occur with subcutaneous administration No significant systemic side effects reported at standard research doses The extensive commercial use of GHK-Cu in cosmetic products provides a broader real-world safety dataset compared to BPC-157

Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

The Power of Combination Protocols Research on peptide combinations demonstrates synergistic effects that exceed the sum of individual components

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