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Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT)

This reflects a key limitation: GLP-1 medications can reduce appetite and support weight loss, but they do not by themselves establish a long-term metabolic framework for maintaining that loss

The results from the Phase 2 study long-term extension over 3 years showed clinically meaningful and significant effects on slowing both cognitive and functional decline and preserved brain volume in individuals with mild cognitive impairment and two copies of the APOE4 genea group that is often unable to take currently available Alzheimers drugs due to safety concerns

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