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[4] Thyroid C-cell tumours: Animal studies have shown an increased risk of medullary thyroid carcinoma, though this has not yet been confirmed in humans

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However, for long-acting GLP-1RAs, such as semaglutide, with a half-life of 1 week, that is not reasonable, as the patient would be deprived of the benefits of the medication for too long (Beam 2023