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Genetic association studies revealed associations of this polymorphism with maternal risk of DS birth either alone (Zampieri et al., 2012b), or in combination with MTR (combined TCN2 776CC/ MTR 2756AG genotype) (Fintelman-Rodrigues et al., 2009) or MTHFR (combined TCN2 776CG/ MTHFR 677TT genotype) (Liao et al., 2014) polymorphisms
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It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics
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