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In a 21-subject clinical study, the serum delivered a 9.45% reduction in wrinkle depth, an 11% improvement in firmness, and a 17.95% boost in hydration over 56 days, all statistically significant

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reported a similar C max to this study (median: 1.69 ng/ml, range: 1.21-1.82 ng/ml) in dogs receiving a 0.02 mg/kg dose on eight consecutive days.[52] This might indicate that in dogs, maximum blood concentrations of rapamycin are more affected by the dose utilized, rather than the frequency or route of administration

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