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Metformin remains the first-line agent recommended by NICE NG28, typically achieving HbA1c reductions of 1.01.5% (1116 mmol/mol), making it more potent than gliptins as a standalone treatment
Ostrominski, J
The novel fixed-dose combination Cagrilintide-Semaglutide (CagriSema), merging a GLP-1 receptor agonist (Semaglutide) with an amylin analog (Cagrilintide), represents a significant therapeutic advance
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