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The more speculative work is happening outside metabolic medicine entirely
TB-500 has demonstrated anti-inflammatory properties in published studies, reducing production of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) while supporting anti-inflammatory mediators
As a dual amylin and calcitonin receptor agonist, cagrilintides mechanism of action centers on binding to the calcitonin receptor (CTR) and the amylin receptor subtypes AMYR, AMYR, and AMYR each formed by the CTR partnered with receptor-activity modifying proteins RAMP1, RAMP2, or RAMP3, respectively
A few amino acid substitutions are responsible for the higher thermostability of a [PMID: 8020473] Laboratory literature summary: A few amino acid substitutions are responsible for the higher thermostability of a novel NAD(+)-dependent bacillar alcohol dehydrogenase
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