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Kainer et al
Although many E1 inhibitors have been developed, except for MLN4924, none has entered clinical trials, most likely due to issues of specificity or poor drug-like properties
In severe cases, the stomach can stop emptying (gastroparesis), which can be serious
According to Sheer, while these results should be interpreted with caution in the absence of prospective and mechanistic studies, they justify this patient population having conversations with their physicians about the appropriateness of GLP-1 therapy as well as the associated risks and benefits
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