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Unlike its established role in CD95-mediated apoptosis of nucleated cells, ceramide promotes eryptosis primarily by enhancing Ca 2+ sensitivity rather than directly facilitating Ca 2+ entry (Gulbins et al., 1995)

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In a 10-2 vote Thursday, the Oncologic Drugs Advisory Committee determined that progression-free survival (PFS) data from the Phase III confirmatory CodeBreaK 200 study could not be reliably interpreted

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GLP-1 stimulates insulin secretion and augments the insulin-releasing effects of glucose on the pancreatic beta cell

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