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Bruni, A., Gala-Lopez, B., Pepper, A
These drugs have anti-fibrotic characteristics by obstructing transforming growth factor- (TGF-) signaling and diminishing collagen accumulation in models of diabetic nephropathy (Tian et al
The release of cytochrome C from the mitochondria leads to production of a caspase-activating complex of cytochrome c, APAF-1, and procaspase-9, triggers the up-regulation of caspase-9, and subsequently increases the expression of caspase-3, followed by the induction of apoptotic events in the cell [44]
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