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On average, Dulcolax (or bisacodyl) will last around 16.5 hours in total

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This reduction suppresses LONP1 expression and activity, leading to mitochondrial dysfunction and elevated oxidative stress [34]

Although most studies suggest that GLP-1RAs promote weight loss mainly due to their inhibitory effect on food intake, other central effects that have been described for native GLP-1 and some GLP-1RAs in rodents and humans encourage future clinical trials to explore additional mechanisms that potentially underlie the beneficial effects observed with this drug class