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GLP-1, or glucagon-like peptide-1, is an incretin hormone produced primarily by enteroendocrine L cells in the small intestine and colon

This is not a simple modification of existing peptide structures

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The inability of the multi-agonists to restore gonadal function in PWA mice is likely due to chronic exposure to fixed concentrations of the exogenous androgen, DHT, which may limit the eventual beneficial effects of the compounds at the gonadal level, even when substantial metabolic improvements are achieved