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Downstream the signalling runs through PI3K/AKT and MAPK/ERK, which is why phospho-AKT and phospho-ERK are the near-universal readouts
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When glutathione levels are depleted - as they consistently are in Hashimoto's thyroiditis, Graves' disease, and hypothyroidism - the consequences cascade: oxidative thyroid damage, protein modification, autoantigen formation, immune activation, and progressive thyroid destruction
Mounjaro (tirzepatide) is FDA approved for Type 2 diabetes but is often prescribed off-label for weight loss
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