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The disturbances are likely to impair diverse aspects of neuronal function including regulation of synaptic transmission, synapse formation, metabolism, interactions with the brain blood supply, propagation of action potentials and neuroprotection
In 2015, triple agonists simultaneously targeting the GLP-1R, GCGR, and GIPR were also developed, whose weight loss in mice exceeded those of the dual agonists [26]
Li D, Yang C, Zhu JZ, Lopez E, Zhang T, Tong Q, et al
A clinical review published in the journal Pediatrics by the American Academy of Pediatrics addressed this directly, stating that the risk of both micronutrient and macronutrient deficiency in children on GLP-1 medications needs to be better characterized, and that careful monitoring of nutritional intake is recommended for every child on these medications
